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Lecture 8 — Cardiac electrophysiology
Phase 0: rapid depolarization via fast Na⁺ channels.
Phase 1: transient K⁺ efflux, early repolarization.
Phase 2: plateau — Ca²⁺ influx balances K⁺ efflux.
Phase 3: repolarization as K⁺ channels dominate.
Phase 4: resting potential maintained by Na⁺/K⁺ ATPase.
SA node sets rate through funny current (If).
Refractory period prevents tetany in cardiac muscle.
Lecture 8 — Cardiac electrophysiology
Phase 0: rapid depolarization via fast Na⁺ channels.
Phase 1: transient K⁺ efflux, early repolarization.
Phase 2: plateau — Ca²⁺ influx balances K⁺ efflux.
Phase 3: repolarization as K⁺ channels dominate.
Phase 4: resting potential maintained by Na⁺/K⁺ ATPase.
SA node sets rate through funny current (If).
Refractory period prevents tetany in cardiac muscle.
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A 24-year-old reports palpitations after starting a new medication. ECG shows a prolonged QT interval. Which ion channel is most likely affected?
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