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Lecture 8 — Cardiac electrophysiology
Phase 0: rapid depolarization via fast Na⁺ channels.
Phase 1: transient K⁺ efflux, early repolarization.
Phase 2: plateau — Ca²⁺ influx balances K⁺ efflux.
Phase 3: repolarization as K⁺ channels dominate.
Phase 4: resting potential maintained by Na⁺/K⁺ ATPase.
SA node sets rate through funny current (If).
Refractory period prevents tetany in cardiac muscle.
Lecture 8 — Cardiac electrophysiology
Phase 0: rapid depolarization via fast Na⁺ channels.
Phase 1: transient K⁺ efflux, early repolarization.
Phase 2: plateau — Ca²⁺ influx balances K⁺ efflux.
Phase 3: repolarization as K⁺ channels dominate.
Phase 4: resting potential maintained by Na⁺/K⁺ ATPase.
SA node sets rate through funny current (If).
Refractory period prevents tetany in cardiac muscle.
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Osmosis
Movement of water across a semipermeable membrane toward higher solute concentration.
Why does the SA node set the heart rate?
It depolarizes fastest, so its rhythm reaches threshold first.
The Treaty of Versailles was signed in 1919, formally ending World War I.
History notes · p. 12
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